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Jack W Singer Selected Research

11- (2- pyrrolidin- 1- ylethoxy)- 14,19- dioxa- 5,7,26- triazatetracyclo(19.3.1.1(2,6).1(8,12))heptacosa- 1(25),2(26),3,5,8,10,12(27),16,21,23- decaene

1/2019Comparative phenotypic profiling of the JAK2 inhibitors ruxolitinib, fedratinib, momelotinib, and pacritinib reveals distinct mechanistic signatures.
11/2018Inhibition of interleukin-1 receptor-associated kinase-1 is a therapeutic strategy for acute myeloid leukemia subtypes.
1/2018Pacritinib vs Best Available Therapy, Including Ruxolitinib, in Patients With Myelofibrosis: A Randomized Clinical Trial.
1/2018Pilot study of the antifibrotic effects of the multikinase inhibitor pacritinib in a mouse model of liver fibrosis.
5/2017Pacritinib versus best available therapy for the treatment of myelofibrosis irrespective of baseline cytopenias (PERSIST-1): an international, randomised, phase 3 trial.
12/2016Phase 1/2 study of pacritinib, a next generation JAK2/FLT3 inhibitor, in myelofibrosis or other myeloid malignancies.
10/2016Synergistic effect of pacritinib with erlotinib on JAK2-mediated resistance in epidermal gowth factor receptor mutation-positive non-small cell lung Cancer.
1/2016Comprehensive kinase profile of pacritinib, a nonmyelosuppressive Janus kinase 2 inhibitor.

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Jack W Singer Research Topics

Disease

16Neoplasms (Cancer)
11/2018 - 10/2003
9Non-Hodgkin Lymphoma (Lymphosarcoma)
01/2020 - 07/2005
7Primary Myelofibrosis (Myelosclerosis)
01/2019 - 01/2016
6Non-Small-Cell Lung Carcinoma (Carcinoma, Non-Small Cell Lung)
10/2016 - 03/2005
4Leukemia
11/2018 - 08/2006
4Cardiotoxicity
07/2014 - 11/2011
3Thrombocytopenia (Thrombopenia)
01/2018 - 07/2012
3Cytopenia
01/2018 - 12/2016
3Neutropenia
07/2012 - 12/2005
2Acute Myeloid Leukemia (Acute Myelogenous Leukemia)
11/2018 - 01/2016
2Necrosis
01/2018 - 04/2005
2Disease Progression
05/2017 - 12/2016
2Myelodysplastic Syndromes (Myelodysplastic Syndrome)
01/2016 - 01/2016
2Lymphoma (Lymphomas)
11/2011 - 07/2005
2Alopecia (Baldness)
06/2008 - 12/2005
2Multiple Myeloma
04/2005 - 12/2003
1Diffuse Large B-Cell Lymphoma (Lymphoma, Large Cell, Diffuse)
01/2020
1Follicular Lymphoma (Lymphoma, Small Cleaved Cell, Follicular)
01/2020
1Inflammation (Inflammations)
09/2018
1Non-alcoholic Fatty Liver Disease
01/2018
1Anemia
01/2018
1Splenomegaly
01/2018
1Fibrosis (Cirrhosis)
01/2018
1Hepatocellular Carcinoma (Hepatoma)
01/2018
1Liver Cirrhosis (Hepatic Cirrhosis)
01/2018
1Liver Diseases (Liver Disease)
01/2018
1Fever (Fevers)
05/2017
1Pneumonia (Pneumonitis)
05/2017
1Sepsis (Septicemia)
05/2017
1Hypotension (Low Blood Pressure)
05/2017
1Heart Failure
05/2017
1Chronic Myelomonocytic Leukemia (Leukemia, Chronic Myelomonocytic)
01/2016
1Weight Loss (Weight Reduction)
07/2014
1Neoplasm Metastasis (Metastasis)
07/2009
1Hypersensitivity (Allergy)
06/2008

Drug/Important Bio-Agent (IBA)

8pixantrone (BBR 2778)IBA
01/2020 - 04/2011
811- (2- pyrrolidin- 1- ylethoxy)- 14,19- dioxa- 5,7,26- triazatetracyclo(19.3.1.1(2,6).1(8,12))heptacosa- 1(25),2(26),3,5,8,10,12(27),16,21,23- decaeneIBA
01/2019 - 01/2016
7Pharmaceutical PreparationsIBA
10/2016 - 03/2005
5paclitaxel poliglumex (XYOTAX)IBA
12/2010 - 03/2005
5Paclitaxel (Taxol)FDA LinkGeneric
06/2008 - 03/2005
52-acylglycerophosphate acyltransferaseIBA
11/2006 - 10/2003
3GemcitabineFDA Link
01/2020 - 07/2008
3ruxolitinibIBA
01/2019 - 01/2018
3AnthraquinonesIBA
07/2014 - 07/2012
3Doxorubicin (Adriamycin)FDA LinkGeneric
07/2014 - 04/2011
3Mitoxantrone (Novantrone)FDA LinkGeneric
02/2013 - 11/2011
3Protein Isoforms (Isoforms)IBA
08/2006 - 10/2003
2Rituximab (Mabthera)FDA Link
01/2020 - 11/2011
2Interleukin-1 Receptor-Associated KinasesIBA
11/2018 - 09/2018
2Janus Kinase 2IBA
01/2018 - 01/2016
2AnthracyclinesIBA
02/2013 - 07/2012
2Vinorelbine (Navelbine)FDA LinkGeneric
07/2012 - 07/2008
2Cathepsin BIBA
03/2007 - 01/2006
2CT-32228IBA
08/2006 - 07/2005
2Glutamic Acid (Glutamate)FDA Link
12/2005 - 03/2005
2Phosphatidic Acids (Phosphatidic Acid)IBA
12/2003 - 10/2003
1fedratinibIBA
01/2019
1Janus Kinase InhibitorsIBA
01/2019
1N- (cyanomethyl)- 4- (2- ((4- (4- morpholinyl)phenyl)amino)- 4- pyrimidinyl)benzamideIBA
01/2019
1Interleukin-1 Receptors (Interleukin 1 Receptor)IBA
11/2018
1Protein Serine-Threonine Kinases (Protein-Serine-Threonine Kinase)IBA
09/2018
1Interleukin-1 (Interleukin 1)IBA
09/2018
1Toll-Like Receptors (Toll-Like Receptor)IBA
09/2018
1Keratin-18 (Keratin 18)IBA
01/2018
1Telmisartan (Micardis)FDA Link
01/2018
1Janus Kinase 1IBA
01/2018
1AngiotensinsIBA
01/2018
1Hemoglobins (Hemoglobin)IBA
01/2018
1CytokinesIBA
01/2018
1Biomarkers (Surrogate Marker)IBA
01/2018
1Erlotinib Hydrochloride (CP 358,774)FDA Link
10/2016
1ErbB Receptors (EGF Receptor)IBA
10/2016
1Tyrosine Kinase InhibitorsIBA
10/2016
1Cytarabine (Cytosar-U)FDA LinkGeneric
01/2016
1Receptor Protein-Tyrosine Kinases (Tyrosine Kinase Receptors)IBA
01/2016
1DecitabineFDA Link
01/2016
1tosedostatIBA
01/2016
1adriamycinolIBA
02/2013
1Hydrogen Peroxide (Hydroperoxide)FDA LinkGeneric
02/2013
1Superoxides (Superoxide)IBA
02/2013
1Etoposide (VP 16)FDA LinkGeneric
07/2012
1IfosfamideFDA LinkGeneric
07/2012
1Oxaliplatin (Eloxatin)FDA LinkGeneric
07/2012
1Dexamethasone (Maxidex)FDA LinkGeneric
11/2011
1fludarabineIBA
11/2011
1Prednisone (Sone)FDA LinkGeneric
04/2011
1Vincristine (Oncovin)FDA LinkGeneric
04/2011
1Cyclophosphamide (Cytoxan)FDA LinkGeneric
04/2011
1DNA (Deoxyribonucleic Acid)IBA
02/2010
1PlatinumIBA
02/2010
1AlbuminsIBA
07/2009
1L-Lactate Dehydrogenase (Lactate Dehydrogenase)IBA
07/2009
1Cisplatin (Platino)FDA LinkGeneric
04/2009

Therapy/Procedure

7Therapeutics
01/2019 - 10/2003
4Drug Therapy (Chemotherapy)
12/2016 - 06/2008
2Salvage Therapy
02/2013 - 07/2012
2Premedication
06/2008 - 12/2005
1Stem Cell Transplantation
01/2020
1Intraperitoneal Injections
07/2014
1Combination Drug Therapy (Combination Chemotherapy)
07/2009